Effect of formulation parameters on 2-methoxyestradiol release from injectable cylindrical poly(dl-lactide-co-glycolide) implants
نویسندگان
چکیده
منابع مشابه
Simvastatin Release from Poly(lactide-co-glycolide)
Statins, a group of potent inhibitors of 3-hydroxy-3-methylglutaryl Coenzyme A reductase in cholesterol biosynthesis pathway, have been widely used as a cholesterol lowering drug. The plieotrophic effect of statins on bone metabolism in long-term usage has been begun to be studied during recent years and several in vitro and in vivo studies have demonstrated the ability of statins to promote ex...
متن کاملEffects of formulation parameters on encapsulation efficiency and release behavior of risperidone poly(D,L-lactide-co-glycolide) microsphere.
A 4-week sustained release risperidone biodegradable poly(D,L-lactide-co-glycolide) (PLGA) microsphere for the therapy of schizophrenia, the effects of formulation parameters on encapsulation efficiency and release behavior were studied. The risperidone PLGA microspheres were prepared by O/W solvent evaporation method and characterized by HPLC, SEM, laser particle size analysis, GC and HPLC-MS....
متن کاملEffect of different formulation variables on some particle characteristics of poly (DL-lactide-co-glycolide) nanoparticles.
This study investigates the effect of some formulation variables on particulate characteristics of poly (DL-lactide-co-glycolide) (PLGA) copolymer nanoparticles by applying 2(3) factorial design and response surface methodology (RSM). Nanoparticles were prepared by solvent displacement technique. Initially, appropriate formulation factors for elaboration of polymeric particles were selected by ...
متن کاملevaluation of polymer concentration effect on doxycycline hyclate drug release from in situforming system based on poly(lactide-co-glycolide)
in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. a...
متن کاملPoly (lactide -co- glycolide) Fiber: An Overview
Co-polymers of lactide and glycolide, referred to as PLGA, have generated tremendous interest because of their excellent biocompatibility, biodegradability and mechanical strength. Various polymeric devices like microspheres, microcapsules, nanoparticles, pellets, implants, and films have been fabricated using these polymers. They can be transformed by spinning into filaments for subsequent fab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2008
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2008.03.007